(3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole

Base Information

• Chemical Name: (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole
• CAS No.: 131035-28-4
• Molecular Formula: C₁₅H₂₁BrN₂
• Molecular Weight: 309.249
• Mol file: 131035-28-4.mol

Synonyms:(3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole

Chemical Property of (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole

There total 3 articles about (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane (68737-65-5) + ortho-bromobenzaldehyde (6630-33-7) → (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole (131035-28-4)

Guidance literature:

DOI:10.1016/S0040-4039(02)01962-7

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole (131035-28-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / benzene

2: lithium aluminum hydride / tetrahydrofuran

With sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; benzene;

DOI:10.1016/S0040-4039(02)01962-7

Reference yield:

(R,R)-(2-ethoxycarbonylaminocyclohexyl)carbamic acid ethyl ester (75730-13-1) → (3aS,7aS)-2-(2-Bromo-phenyl)-1,3-dimethyl-octahydro-benzoimidazole (131035-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminum hydride / tetrahydrofuran

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(02)01962-7

upstream raw materials:

(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane

ortho-bromobenzaldehyde

(R,R)-(2-ethoxycarbonylaminocyclohexyl)carbamic acid ethyl ester

(1R,2R)-1,2-diaminocyclohexane