3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Base Information

Chemical Name:3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester
CAS No.:204916-06-3
Molecular Formula:C₁₈H₂₁IN₄O₄
Molecular Weight:484.294
Hs Code.:

3-[3-(allyl-<i>tert</i>-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Synonyms:3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Suppliers and Price of 3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

There total 9 articles about 3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 204916-05-2
3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-3-hydroxy-propionic acid methyl ester

: 204916-06-3
3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jo990464j

Reference yield:

: 5398-69-6
2-iodo-3-nitrobenzoic acid

: 204916-06-3
3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: B(OME)3 / tetrahydrofuran / 1.5 h / Heating

2: 75.8 g / DMAP; ET₃N / CH₂Cl₂ / 0.17 h / 0 °C

3: 91 percent / Fe; AcOH / aq. ethanol / 0.25 h / Heating

4: 48 percent / dioxane / 48 h / Heating

5: NaH / dimethylformamide / 1 h / 0 - 20 °C

6: aq. K₂CO₃ / methanol / 0.25 h / 20 °C

7: 25.3 g / MnO₂ / ethyl acetate / 32 h / Heating

8: 64 percent / NaHMDS / tetrahydrofuran / 1.75 h / -78 °C

9: 84 percent / MsCl; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; manganese(IV) oxide; Trimethyl borate; sodium hexamethyldisilazane; iron; sodium hydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Reduction / 2: Esterification / 3: Reduction / 4: Acylation / 5: Alkylation / 6: Hydrolysis / 7: Oxidation / 8: Condensation / 9: Dehydration;
DOI:10.1021/jo990464j

Reference yield:

: 158616-08-1
(2-iodo-3-nitrophenyl)methanol

: 204916-06-3
3-[3-(allyl-tert-butoxycarbonyl-amino)-2-iodo-phenyl]-2-azido-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 75.8 g / DMAP; ET₃N / CH₂Cl₂ / 0.17 h / 0 °C

2: 91 percent / Fe; AcOH / aq. ethanol / 0.25 h / Heating

3: 48 percent / dioxane / 48 h / Heating

4: NaH / dimethylformamide / 1 h / 0 - 20 °C

5: aq. K₂CO₃ / methanol / 0.25 h / 20 °C

6: 25.3 g / MnO₂ / ethyl acetate / 32 h / Heating

7: 64 percent / NaHMDS / tetrahydrofuran / 1.75 h / -78 °C

8: 84 percent / MsCl; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; manganese(IV) oxide; sodium hexamethyldisilazane; iron; sodium hydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Esterification / 2: Reduction / 3: Acylation / 4: Alkylation / 5: Hydrolysis / 6: Oxidation / 7: Condensation / 8: Dehydration;
DOI:10.1021/jo990464j