Technology Process of 3-[3-(4-methylpiperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine
There total 5 articles about 3-[3-(4-methylpiperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-[3-(piperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine hydrochloride;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 25 ℃;
for 0.333333h;
formaldehyd;
In
water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C
2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube
3: hydrogenchloride / methanol / 5 h / 55 °C
4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 25 °C
With
hydrogenchloride; bromine; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium tert-butylate / palladium diacetate; (R)-(-)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 1,4-dioxane / 100 °C / Inert atmosphere
2: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C
3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube
4: hydrogenchloride / methanol / 5 h / 55 °C
5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.33 h / 25 °C
With
hydrogenchloride; potassium tert-butylate; bromine; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (R)-(-)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
1: Hartwig-Buchwald reaction;
