(R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Base Information

• Chemical Name: (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide
• CAS No.: 1404054-53-0
• Molecular Formula: Br*C₃₁H₃₃F₂N₂O₃
• Molecular Weight: 599.515
• Mol file: 1404054-53-0.mol

Synonyms:(R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Chemical Property of (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide

There total 3 articles about (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-5-(2-bromoethyl)benzofuran (127264-14-6) + (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate (1404054-16-5) → (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-53-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 192h;

Reference yield:

(3R)-quinuclidin-3-amine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; methanol / 1 h / 20 °C

1.2: 7 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 48 h / 20 °C

3.1: ethyl acetate / 192 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

bis(3-fluorophenyl)methanol (98586-21-1) → (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide (1404054-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; methanol / 1 h / 20 °C

1.2: 16 h / 20 °C

1.3: 48 h / 20 °C

2.1: 192 h / 20 °C

With sodium hydrogencarbonate; In methanol; water;

upstream raw materials:

2,3-dihydro-5-(2-bromoethyl)benzofuran

(R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate

(3R)-quinuclidin-3-amine dihydrochloride

bis(3-fluorophenyl)methanol