N-[(1S)-1-phenylethyl]-4-hexynamide

Base Information

Chemical Name:N-[(1S)-1-phenylethyl]-4-hexynamide
CAS No.:208844-34-2
Molecular Formula:C₁₄H₁₇NO
Molecular Weight:215.295
Hs Code.:

Synonyms:N-[(1S)-1-phenylethyl]-4-hexynamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S)-1-phenylethyl]-4-hexynamide

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Technology Process of N-[(1S)-1-phenylethyl]-4-hexynamide

There total 6 articles about N-[(1S)-1-phenylethyl]-4-hexynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41143-12-8
hex-4-ynoic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 208844-34-2
N-[(1S)-1-phenylethyl]-4-hexynamide

Guidance literature:: With triethylamine; diethyl dicarbonate; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(98)00520-6

Reference yield:

4-hexyn-1-ol: 928-93-8
4-hexyn-1-ol

: 208844-34-2
N-[(1S)-1-phenylethyl]-4-hexynamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 2,2,6,6-tetramethylpiperidine 1-oxyl; NaClO; NaClO₂ / acetonitrile; H₂O / 5 h / 37 °C / pH 6.86

2: DEPC; Et₃N / tetrahydrofuran / 0 - 20 °C

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; diethyl dicarbonate; In tetrahydrofuran; water; acetonitrile; 1: Oxidation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00841-3

Reference yield:

: 61362-77-4
5-[tert-butyldimethylsilyloxy]pent-1-yne

: 208844-34-2
N-[(1S)-1-phenylethyl]-4-hexynamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -5 °C

1.2: 90 percent / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 10 h / 20 °C

2.1: HF / acetonitrile / 0.5 h / 20 °C

3.1: 76 percent / 2,2,6,6-tetramethylpiperidine 1-oxyl; NaClO; NaClO₂ / acetonitrile; H₂O / 5 h / 37 °C / pH 6.86

4.1: DEPC; Et₃N / tetrahydrofuran / 0 - 20 °C

With sodium hypochlorite; sodium chlorite; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen fluoride; triethylamine; diethyl dicarbonate; In tetrahydrofuran; hexane; water; acetonitrile; 1.1: Deprotonation / 1.2: Methylation / 2.1: Hydrolysis / 3.1: Oxidation / 4.1: Condensation;
DOI:10.1016/S0040-4020(00)00841-3