(5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone

Base Information

Chemical Name:(5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone
CAS No.:321309-76-6
Molecular Formula:C₁₄H₁₇NO
Molecular Weight:215.295
Hs Code.:
DSSTox Substance ID:DTXSID701199308
Nikkaji Number:J1.419.558K

Synonyms:DTXSID701199308;321309-76-6;(5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone

Suppliers and Price of (5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:215.131014166
Heavy Atom Count:16
Complexity:289

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC=C1CCC(=O)N1C(C)C2=CC=CC=C2
Isomeric SMILES:C/C=C\1/CCC(=O)N1[C@@H](C)C2=CC=CC=C2

Technology Process of (5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone

There total 7 articles about (5Z)-5-Ethylidene-1-[(1S)-1-phenylethyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 208844-34-2
N-[(1S)-1-phenylethyl]-4-hexynamide

: 321309-76-6
(Z)-N-[(1S)-(1-phenylethyl)]-5-ethylidene-2-pyrrolidinone

Guidance literature:: With silver trifluoromethanesulfonate; lithium hexamethyldisilazane; In hexane; toluene; at 65 - 70 ℃; for 3h;
DOI:10.1016/S0040-4039(98)00520-6

Reference yield:

4-hexyn-1-ol: 928-93-8
4-hexyn-1-ol

: 321309-76-6
(Z)-N-[(1S)-(1-phenylethyl)]-5-ethylidene-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / 2,2,6,6-tetramethylpiperidine 1-oxyl; NaClO; NaClO₂ / acetonitrile; H₂O / 5 h / 37 °C / pH 6.86

2: DEPC; Et₃N / tetrahydrofuran / 0 - 20 °C

3: 89 percent / LiN(TMS)2; AgOTf / toluene; hexane / 3.5 h / 20 - 70 °C

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; silver trifluoromethanesulfonate; triethylamine; diethyl dicarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; water; toluene; acetonitrile; 1: Oxidation / 2: Condensation / 3: Cyclization;
DOI:10.1016/S0040-4020(00)00841-3

Reference yield:

: 41143-12-8
hex-4-ynoic acid

: 321309-76-6
(Z)-N-[(1S)-(1-phenylethyl)]-5-ethylidene-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: DEPC; Et₃N / tetrahydrofuran / 0 - 20 °C

2: 89 percent / LiN(TMS)2; AgOTf / toluene; hexane / 3.5 h / 20 - 70 °C

With silver trifluoromethanesulfonate; triethylamine; diethyl dicarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene; 1: Condensation / 2: Cyclization;
DOI:10.1016/S0040-4020(00)00841-3