N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

Base Information

Chemical Name:N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide
CAS No.:1004761-76-5
Molecular Formula:C₂₅H₁₉ClF₃N₃O₄
Molecular Weight:517.892
Hs Code.:

Synonyms:N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

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Chemical Property of N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

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Technology Process of N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

There total 5 articles about N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: N-[2,6-dimethyl-4-(1-trifluoromethyl-vinyl)-phenyl]-3-nitro-benzamide

: 3848-36-0
4-chlorobenzaldoxime

: 1004761-76-5
N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

Guidance literature:: 4-chlorobenzaldoxime; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

N-[2,6-dimethyl-4-(1-trifluoromethyl-vinyl)-phenyl]-3-nitro-benzamide; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 24596-19-8
4-bromo-2,6-dimethylphenylamine

: 1004761-76-5
N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 80 °C

2.1: sodium hydroxide / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / tetrahydrofuran; 1,2-dimethoxyethane; water / 0.17 h / 0 - 130 °C / Sealed tube; Microwave irradiation

3.1: triethylamine / toluene / 4 h / 0 - 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 3 h / 20 °C

With sodium hydroxide; N-chloro-succinimide; potassium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1004761-68-5
2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1004761-76-5
N-{4-[3-(4-chloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-yl]-2,6-dimethyl-phenyl}-3-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / tetrahydrofuran; 1,2-dimethoxyethane; water / 0.17 h / 0 - 130 °C / Sealed tube; Microwave irradiation

2.1: triethylamine / toluene / 4 h / 0 - 20 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 3 h / 20 °C

With sodium hydroxide; N-chloro-succinimide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;