toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Base Information

Chemical Name:toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester
CAS No.:372523-26-7
Molecular Formula:C₂₃H₂₁NO₅S
Molecular Weight:423.489
Hs Code.:

Synonyms:toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Suppliers and Price of toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

There total 6 articles about toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 372523-11-0
toluene-3-sulfonic acid 3-[2-(3-allyloxy-4-cyanophenyl)ethoxy]-5-methylphenyl ester

: 372523-26-7
toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Guidance literature:: With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm010833f

Reference yield:

: 13398-94-2
2-(3-hydroxyphenyl)ethanol

: 372523-26-7
toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / NaHSO₄*SiO₂ / hexane / 22 h / Heating

2.1: CH₃CH₂MgBr / tetrahydrofuran / 0.5 h

2.2: 96 percent / Et₃N / benzene / 3 h / Heating

3.1: 85 percent / K₂CO₃; MeOH / CHCl₃ / Heating

4.1: 60 percent / NaOAc; nitroethane / Heating

5.1: 77 percent / K₂CO₃; MeOH / 2 h / Heating

6.1: 35 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

7.1: 78 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium tetrahydroborate; sodium hydrogen sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Nitroethane; ethylmagnesium bromide; sodium acetate; silica gel; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; chloroform; 6.1: Mitsunobu reaction;
DOI:10.1021/jm010833f

Reference yield:

: 372522-89-9
acetic acid 2-(4-formyl-3-hydroxyphenyl)ethyl ester

: 372523-26-7
toluene-3-sulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-methylphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / K₂CO₃; MeOH / CHCl₃ / Heating

2: 60 percent / NaOAc; nitroethane / Heating

3: 77 percent / K₂CO₃; MeOH / 2 h / Heating

4: 35 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

5: 78 percent / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Nitroethane; sodium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; chloroform; 4: Mitsunobu reaction;
DOI:10.1021/jm010833f