4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

Base Information

Chemical Name:4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one
CAS No.:1018680-64-2
Molecular Formula:C₂₀H₁₈ClN₅O₃
Molecular Weight:411.848
Hs Code.:

Synonyms:4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

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Chemical Property of 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

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Technology Process of 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

There total 10 articles about 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 934282-60-7
(R)-1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethanol

: 1018681-03-2
4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-1-methyl-1H-pyridin-2-one

: 1018680-64-2
4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 57961-48-5
ethyl 4-(3-chlorophenyl)-2,4-dioxobutanoate

: 1018680-64-2
4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride / methanol / 4 h / 80 °C

2.1: triethylamine / tetrahydrofuran; diethyl ether; toluene / 5 h / 0 °C

2.2: 0.5 h / 45 °C

3.1: sodium tetrahydroborate / methanol / 3 h / 20 °C

4.1: Novozyme 435.(R). / toluene / 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C

With lithium hydroxide; sodium tetrahydroborate; hydroxylamine hydrochloride; water; caesium carbonate; triethylamine; Novozyme 435; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: 657424-83-4
1-[5-(3-Chloro-phenyl)-isoxazol-3-yl]-ethanone

: 1018680-64-2
4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 3 h / 20 °C

2: Novozyme 435.(R). / toluene / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 60 °C

With lithium hydroxide; sodium tetrahydroborate; water; caesium carbonate; Novozyme 435; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;