657424-83-4

Upstream product

• 657424-77-6 ethyl 5-(3-chlorophenyl)isoxazole-3-carboxylate 
• 917-64-6 methyl magnesium iodide 
• 660417-41-4 5-(3-chloro-phenyl)-isoxazole-3-carboxylic acid methyl ester 
• 75-16-1 methylmagnesium bromide 
• 57961-48-5 ethyl 4-(3-chlorophenyl)-2,4-dioxobutanoate 

Downstream Products

• 934282-60-7 (R)-1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethanol 
• 1196958-60-7 (1S)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethanol 
• 1018680-68-6 4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one 
• 1018680-64-2 4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)-1-methylpyridin-2(1H)-one 
• 934282-59-4 (1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethyl acetate 
• 657427-36-6 1-[5-(3-chlorophenyl)isoxazol-3-yl]ethanol 

Relevant academic research and scientific papers

NEW PROCESS FOR THE PREPARATION OF 1- [5- (3-CHLORO-PHENYL) - ISOOXAZOL-3-YL] -ETHANONE AND (R) -1- [5- (3-CHLORO-PHENYL) - ISOOXAZOL-3-YL] -ETHANOL

The present invention provides a process for the preparation of the compound 1- [5- (3-chloro-phenyl) -isooxazol-3-yl] - ethanone: Wherein the compound 5- (3-chlorophenyl) -isooxazol-3- carboxylate is reacted with CH3MgX. The present invention also provid

MGLUR5 MODULATORS

The present invention is directed to compounds of formula (I) Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in

MGluR5 modulators VI

The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

NEW COMPOUNDS

The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.