Chemical Property of Sulfapyridine
Chemical Property:
- Appearance/Colour:white or yellowish-white crystalline powder
- Vapor Pressure:3.9E-09mmHg at 25°C
- Melting Point:191-193 °C
- Refractive Index:1.674
- Boiling Point:473.5 °C at 760 mmHg
- PKA:pKa 8.48(H2O
t = 25
I = 0.05) (Uncertain)
- Flash Point:240.2 °C
- PSA：93.46000
- Density:1.432 g/cm3
- LogP:3.19960
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Water Solubility.:<0.1 g/100 mL at 22℃
- XLogP3:0
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:249.05719778
- Heavy Atom Count:17
- Complexity:331
- Purity/Quality:
-
99%, *data from raw suppliers
THAP11 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
22-24/25-36-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
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Description
Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. It is also a metabolite of sulfasalazine formed through bacterial conversion in the colon. It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM). It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC50 = 0.18 μM). Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay. It inhibits histamine release induced by compound 48/80 from isolated rat peritoneal mast cells in a dose-dependent manner. Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.
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Uses
Used in treatment of dermatitis herpetiformis; antibacterial. antibacterial, dermatitis herpetiformis therapy
