Sulfapyridine

Base Information Edit

Chemical Name:Sulfapyridine
CAS No.:144-83-2
Molecular Formula:C11H11N3O2S
Molecular Weight:249.293
Hs Code.:29350010
European Community (EC) Number:205-642-7
NSC Number:757329,41791,4753
UNII:Y5V2N1KE8U
DSSTox Substance ID:DTXSID3026067
Nikkaji Number:J5.831I
Wikipedia:Sulfapyridine
Wikidata:Q3976827
NCI Thesaurus Code:C66570
Metabolomics Workbench ID:43165
ChEMBL ID:CHEMBL700
Mol file:144-83-2.mol

Synonyms:Sulfapyridine;Sulphapyridin;Sulphapyridine

Suppliers and Price of Sulfapyridine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
THAP11
100ug
$ 539.00

Usbiological
Sulfapyridine
500ul
$ 523.00

Usbiological
Sulfapyridine
100g
$ 247.00

TRC
Sulfapyridine
250mg
$ 325.00

TCI Chemical
Sulfapyridine >98.0%(HPLC)(T)
25g
$ 41.00

SynQuest Laboratories
Sulfa pyridine 98.0%
100 g
$ 68.00

Sigma-Aldrich
Sulfapyridine VETRANAL?, analytical standard
250mg
$ 47.50

Sigma-Aldrich
Sulfapyridine European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Sulfapyridine European Pharmacopoeia (EP) Reference Standard
s2159100
$ 190.00

Sigma-Aldrich
Sulfapyridine ≥99.0%
100g
$ 183.00

Total 97 raw suppliers

Chemical Property of Sulfapyridine Edit

Chemical Property:

Appearance/Colour:white or yellowish-white crystalline powder
Vapor Pressure:3.9E-09mmHg at 25°C
Melting Point:191-193 °C
Refractive Index:1.674
Boiling Point:473.5 °C at 760 mmHg
PKA:pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)
Flash Point:240.2 °C
PSA：93.46000
Density:1.432 g/cm³
LogP:3.19960
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:<0.1 g/100 mL at 22℃
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:249.05719778
Heavy Atom Count:17
Complexity:331

Purity/Quality:

99% ^*data from raw suppliers

THAP11 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 22-24/25-36-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Description Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. It is also a metabolite of sulfasalazine formed through bacterial conversion in the colon. It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM). It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC50 = 0.18 μM). Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay. It inhibits histamine release induced by compound 48/80 from isolated rat peritoneal mast cells in a dose-dependent manner. Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.
Uses Used in treatment of dermatitis herpetiformis; antibacterial. antibacterial, dermatitis herpetiformis therapy

Technology Process of Sulfapyridine

There total 24 articles about Sulfapyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%