6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

Base Information

Chemical Name:6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester
CAS No.:146953-69-7
Molecular Formula:C₂₈H₄₃N₅O₁₀
Molecular Weight:609.677
Hs Code.:

Synonyms:6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

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Chemical Property of 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

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Technology Process of 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

There total 4 articles about 6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7598-70-1
diethyl 2-(4-nitrobenzyl)malonate

: 146953-69-7
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / methanol / 312 h / Heating

2: 1) BH₃*THF, 2) concd. HCl / 1) THF, reflux, 2) H₂O, reflux

3: 1) K₂CO₃ / 1) DMF, r. t., 2) r. t.

With hydrogenchloride; borane-THF; potassium carbonate; In methanol;
DOI:10.1021/jo00059a062

Reference yield:

: 112-24-3
triethylentetramine

: 146953-69-7
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / methanol / 312 h / Heating

2: 1) BH₃*THF, 2) concd. HCl / 1) THF, reflux, 2) H₂O, reflux

3: 1) K₂CO₃ / 1) DMF, r. t., 2) r. t.

With hydrogenchloride; borane-THF; potassium carbonate; In methanol;
DOI:10.1021/jo00059a062

Reference yield:

: 128924-89-0
12-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclotridecane-11,13-dione

: 146953-69-7
6-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid tetramethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) BH₃*THF, 2) concd. HCl / 1) THF, reflux, 2) H₂O, reflux

2: 1) K₂CO₃ / 1) DMF, r. t., 2) r. t.

With hydrogenchloride; borane-THF; potassium carbonate;
DOI:10.1021/jo00059a062