112-24-3 Usage
Description
Cross sensitivity is
possible with diethylenetriamine and diethylenediamine.
Chemical Properties
Triethylenetetramine is a corrosive liquid.
Uses
Different sources of media describe the Uses of 112-24-3 differently. You can refer to the following data:
1. Triethylenetetramine is used as an amine hardener in
epoxy resin of the bisphenol A type.
2. Triethylenetetramine is used in synthesis of detergents, softeners, and dyestuffs; manufacture of pharmaceuticals; vulcanization accelerator of rubber;
thermo setting resin; epoxy curing agent; lubricating-oil additive; analytical reagent for Cu, Ni; chelating agent; treatment of Wilson's disease.
3. Triethylenetetramine is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.
Production Methods
TETA is manufactured by reacting ethylene dichloride and
ammonia under controlled conditions.
Brand name
Syprine (Merck).
General Description
A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.
Reactivity Profile
Triethylenetetramine is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).
Health Hazard
Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility
Nonflammable
Contact allergens
Triethylenetetramine is used as an amine hardener in
epoxy resins of the bisphenol A type. Cross-sensitivity is
possible with diethylenetriamine and diethylenediamine.
Safety Profile
Poison by intravenous
route. Moderately toxic by ingestion and
skin contact. An experimental teratogen.
Experimental reproductive effects. Mutation
data reported. A corrosive irritant to skin,
eyes, and mucous membranes. Causes skin
sensitization. Combustible when exposed to
heat or flame. Ignites on contact with
cellulose nitrate of high surface area. Can
react with oxidizing materials. To fight fire,
use CO2, dry chemical, alcohol foam. When
heated to decomposition it emits toxic
fumes of NOx.
Carcinogenicity
TETA was mutagenic in bacterial assays
and was positive in sister chromatid exchanges
and unscheduled DNA synthesis tests in vitro.8
It was not clastogenic in the mouse micronucleus
test in vivo after oral or intraperitoneal
administration.
Purification Methods
Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.]
Check Digit Verification of cas no
The CAS Registry Mumber 112-24-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112-24:
(5*1)+(4*1)+(3*2)+(2*2)+(1*4)=23
23 % 10 = 3
So 112-24-3 is a valid CAS Registry Number.
InChI:InChI:1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
112-24-3Relevant articles and documents
-
Schwarzenbach
, p. 974,983 (1950)
-
Synthesis and Bioevaluation of Macrocycle-Polyamine Conjugates as Cell Migration Inhibitors
Skruber, Kristen,Chaplin, Kelvin J.,Phanstiel, Otto
, p. 8606 - 8619 (2017)
The motuporamines are natural products isolated from the New Guinea sea sponge Xestospongia exigua. Dihydromotuporamine C contains a large macrocycle and an appended polyamine component and was shown to be both antimetastatic and cytotoxic to human L3.6pl pancreatic cancer cells. A series of macrocycle-polyamine conjugates were prepared, and the sequence of the polyamine component was varied to optimize the antimigration properties (as measured in L3.6pl cells) of this molecular class. A one-carbon spacer between the 15-membered carbocycle and the appended polyamine showed improved antimigration properties. A survey of different polyamine sequences containing two, three, or four carbon spacers revealed that the natural polyamine sequence (norspermidine, a 3,3-triamine) was superior in terms of inhibiting the migration of L3.6pl cells in vitro. An investigation of the respective ceramide and sphingomyelin populations in L3.6pl cells revealed that these molecules can modulate both ceramide and sphingomyelin pools in cells and inhibit cell migration.
Propanil emulsifiable concentrate herbicide and preparation method thereof
-
Paragraph 0040; 0068; 0076; 0078; 0086; 0088; 0096, (2021/10/27)
The invention discloses a propanil emulsifiable concentrate herbicide, belongs to the technical field of herbicides, and comprises the following raw materials in percentage by weight: 1 - 35% parts of propanil. Ether 1 - 20%, isophorone 1 - 20%, crowndaisy chrysanthemum extract 4 - 15%, potassium nitrate 2 - 10%, emulsifier 3 - 5%, dispersant 1 - 3%, defoaming agent 1 - 3%, ultraviolet absorber 3 - 6%, vegetable oil 10 - 20% and the balance are carrier. The invention further discloses a preparation method of the herbicide. In the herbicide formula, the ultraviolet absorbent is added in the herbicide formula, so that the compound herbicide has the effects of oxidation resistance, aging resistance, ultraviolet aging resistance, effective component visible light decomposition, and persistent drug effect.
PROCESS TO CONVERT THE CYCLIC MONOUREA OF AN ETHYLENE AMINE COMPOUND INTO THE ETHYLENE AMINE COMPOUND
-
Page/Page column 9-10, (2019/02/25)
The present invention relates to a process to convert the cyclic monourea of ethylene amine compounds (U-EA) into ethylene amine compound (EA) by performing a reactive separation step using a reaction mixture containing the cyclic monourea, wherein one cyclic monourea (U-EA) reacts with another cyclic monourea (U-EA) to transfer its urea unit thereto and the obtained ethylene amine compound (EA) without urea unit is separated from the reaction mixture.