(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

Base Information

Chemical Name:(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine
CAS No.:1195985-44-4
Molecular Formula:C₂₀H₂₁Cl₂N₃O
Molecular Weight:390.312
Hs Code.:

Synonyms:(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

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Chemical Property of (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

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Technology Process of (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

There total 5 articles about (1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1195985-63-7
1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone

: 24358-43-8,68297-62-1,147200-14-4,17061-53-9
(R)-α-(m-chlorophenyl)ethylamine

: 1195985-44-4
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: 1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethanone; (R)-α-(m-chlorophenyl)ethylamine; With titanium(IV) isopropylate; In tetrahydrofuran; at 35 ℃; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 ℃; Inert atmosphere;
DOI:10.1021/jm9012278

Reference yield:

: 3-chlorophenylhydrazine dihydrochloride

: 1195985-44-4
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

1.2: 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 0 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 5 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

6.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; di-isopropyl azodicarboxylate; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene; 2.1: Mitsunobu reaction / 5.1: Grignard reaction;
DOI:10.1021/jm9012278

Reference yield:

: 55983-75-0
1-(3-chlorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid

: 1195985-44-4
(1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophenyl)-5-methoxy-1H-pyrazol-3-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: titanium(IV) isopropylate / tetrahydrofuran / 35 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Grignard reaction;
DOI:10.1021/jm9012278