1,2-Bis(4-hydroxy-benzylidene)hydrazine

Base Information

• Chemical Name: 1,2-Bis(4-hydroxy-benzylidene)hydrazine
• CAS No.: 5466-23-9
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.261
• Hs Code.: 2928000090
• Mol file: 5466-23-9.mol

Synonyms:CBDivE_002216;SCHEMBL9621788;HMS2636C11;HMS3363D01;1,2-bis(4-hydroxy-benzylidene)hydrazine

Chemical Property of 1,2-Bis(4-hydroxy-benzylidene)hydrazine

Chemical Property:

• Boiling Point: 355.2oC at 760 mmHg
• Flash Point: 135.2oC
• PSA: 65.18000
• Density: 1.416g/cm3
• LogP: 2.55080
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 240.089877630
• Heavy Atom Count: 18
• Complexity: 258

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxybenzaldehyde [(1E)-(4-hydroxyphenyl)-methylene]hydrazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=NN=CC2=CC=C(C=C2)O)O

Technology Process of 1,2-Bis(4-hydroxy-benzylidene)hydrazine

There total 10 articles about 1,2-Bis(4-hydroxy-benzylidene)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

hydrazine-hydroquinone complex (97108-34-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → bis(4-hydroxybenzylidene)hydrazine (5466-23-9) + hydroquinone (123-31-9,8027-02-9)

Guidance literature:

at 25 - 30 ℃; for 1h; Further Variations:; Reaction partners; Reaction types; Product distribution; solid state, in ball mill;

DOI:10.1002/1099-1395(200007)13:7<388::AID-POC278>3.0.CO;2-H

Reference yield: 98.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → bis(4-hydroxybenzylidene)hydrazine (5466-23-9)

Guidance literature:

With carbazic acid; at 60 ℃; for 10h; Neat (no solvent);

DOI:10.1021/ol202593g

Reference yield: 96.0%

4-Vinylphenylboronic acid (2156-04-9,593231-72-2) → bis(4-hydroxybenzylidene)hydrazine (5466-23-9)

Guidance literature:

With 1,3-dimethyl-5-ethyl-4a-hydroperoxyalloxazine; oxygen; hydrazine hydrate; In methanol; 2,2,2-trifluoroethanol; at 20 ℃; for 1h; under 760.051 Torr;

DOI:10.1039/c3ob42081g

upstream raw materials:

4-hydroxy-benzaldehyde

hydrazine-hydroquinone complex

trichlorofluoromethane

1,1,1-tribromotrifluoroethane

Downstream raw materials:

4-(4-methylbenzyl)phenol

4-hydroxy-benzaldehyde

Refernces

• 1、 Goudgaon,Upendar Reddy, Ch.,Patil, Sharanabasappa,Sheshikant. "Anomalous reaction of hydrazine hydrate with 5-arylidene barbiturates: Formation of benzalazines". . p. 277 - 282. Retrieved 2019/01/21.
• 2、 Lee, Byeongno,Hyung Lee, Kyu,Cho, Jaeheung,Nam, Wonwoo,Hur, Nam Hwi. "Synthesis of azines in solid state: Reactivity of solid hydrazine with aldehydes and ketones". supporting information; experimental part. p. 6386 - 6389. Retrieved 2012/02/01.