benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate

Base Information

• Chemical Name: benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate
• CAS No.: 869969-85-7
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 869969-85-7.mol

Synonyms:benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate

Chemical Property of benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate

There total 2 articles about benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-iodo-methyl-benzoic acid (610-97-9) + benzyl 3-oxopyrrolidine-1-carboxylate (130312-02-6) → benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate (869969-85-7)

Guidance literature:

o-iodo-methyl-benzoic acid; With isopropylmagnesium bromide; In tetrahydrofuran; at -60 - -50 ℃; for 1h;

benzyl 3-oxopyrrolidine-1-carboxylate; In tetrahydrofuran; at -20 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

benzyl 3-oxopyrrolidine-1-carboxylate (130312-02-6) → benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate (869969-85-7)

Guidance literature:

o-iodo-methyl-benzoic acid; With isopropylmagnesium bromide; In tetrahydrofuran; at -60 - -50 ℃; for 1h;

benzyl 3-oxopyrrolidine-1-carboxylate; In tetrahydrofuran; at -50 - -20 ℃; for 2h;

Reference yield:

benzyl 3-oxo-1'H,3H-spiro[2-benzofuran-1,3'-pyrrolidine]-1'-carboxylate (869969-85-7) → 1,3-dihydrospiro[isobenzofuran-1,3'-pyrrolidine]-3-one (56658-23-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 4h;

upstream raw materials:

benzyl 3-oxopyrrolidine-1-carboxylate

o-iodo-methyl-benzoic acid

Downstream raw materials:

1,3-dihydrospiro[isobenzofuran-1,3'-pyrrolidine]-3-one