2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

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Chemical Name:2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole
CAS No.:929507-06-2
Molecular Formula:C₂₃H₁₈FN₃OS₂
Molecular Weight:435.546
Hs Code.:

Synonyms:2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

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Chemical Property of 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

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Technology Process of 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

There total 4 articles about 2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1019177-86-6
C₁₄H₁₂FN₃S₂

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 929507-06-2
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1016/j.bmc.2014.11.029

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 929507-06-2
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Reflux

2.1: ethanol / 1 h / 80 °C

2.2: 4 h

3.1: ethanol / 5 h / 80 °C

In ethanol;
DOI:10.1016/j.bmcl.2012.05.091

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 929507-06-2
2-(3-(4-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-(4-methoxyphenyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Reflux

2.1: ethanol / 1 h / 80 °C

2.2: 4 h

3.1: ethanol / 5 h / 80 °C

In ethanol;
DOI:10.1016/j.bmcl.2012.05.091