N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

Base Information

Chemical Name:N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester
CAS No.:764693-24-5
Molecular Formula:C₂₇H₃₄F₅NO₅Si
Molecular Weight:575.648
Hs Code.:

Synonyms:N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

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Chemical Property of N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

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Technology Process of N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

There total 3 articles about N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70989-89-8
Boc-Thr(Bzl)-OPfp

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 764693-24-5
N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/ja053711b

Reference yield:

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 764693-24-5
N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 3 h / 20 °C

2: 1.2 g / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ja053711b

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 764693-24-5
N-(triisopropylsilyloxycarbonyl)-O-(benzyl)-L-threonine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 3 h / 20 °C

2: 1.2 g / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ja053711b