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15260-10-3

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15260-10-3 Usage

Chemical Properties

White crystalline

Uses

Boc-O-benzyl-L-threonine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Check Digit Verification of cas no

The CAS Registry Mumber 15260-10-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,6 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 15260-10:
(7*1)+(6*5)+(5*2)+(4*6)+(3*0)+(2*1)+(1*0)=73
73 % 10 = 3
So 15260-10-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO5/c1-5(11)6(7(12)13)10-8(14)15-9(2,3)4/h5-6,11H,1-4H3,(H,10,14)(H,12,13)/t5-,6+/m1/s1

15260-10-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (B1630)  N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine  >98.0%(HPLC)(T)

  • 15260-10-3

  • 5g

  • 640.00CNY

  • Detail
  • Alfa Aesar

  • (B21677)  N-Boc-O-benzyl-L-threonine, 99%   

  • 15260-10-3

  • 1g

  • 352.0CNY

  • Detail
  • Alfa Aesar

  • (B21677)  N-Boc-O-benzyl-L-threonine, 99%   

  • 15260-10-3

  • 5g

  • 759.0CNY

  • Detail
  • Aldrich

  • (15405)  Boc-Thr(Bzl)-OH  ≥99.0% (T)

  • 15260-10-3

  • 15405-5G

  • 1,079.91CNY

  • Detail

15260-10-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxybutanoic acid

1.2 Other means of identification

Product number -
Other names N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine,Boc-O-benzyl-L-threonine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15260-10-3 SDS

15260-10-3Synthetic route

Boc-Thr-OH
2592-18-9

Boc-Thr-OH

benzyl bromide
100-39-0

benzyl bromide

N-Boc-O-benzyl-L-threonine
15260-10-3

N-Boc-O-benzyl-L-threonine

Conditions
ConditionsYield
Stage #1: Boc-Thr-OH With sodium hydride In N,N-dimethyl-formamide; mineral oil at -20℃; for 2h; Inert atmosphere;
Stage #2: benzyl bromide In N,N-dimethyl-formamide; mineral oil at 20 - 25℃; for 3h;
90%
Stage #1: Boc-Thr-OH With sodium hydride In N,N-dimethyl-formamide at -20℃; for 2h; Inert atmosphere;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere;
80%
Stage #1: Boc-Thr-OH With sodium hydride In N,N-dimethyl-formamide at -20℃; for 2h; Inert atmosphere;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 12h; Time;
71%
N-Boc-Thr(OBn)-PAM resin

N-Boc-Thr(OBn)-PAM resin

N-Boc-O-benzyl-L-threonine
15260-10-3

N-Boc-O-benzyl-L-threonine

Conditions
ConditionsYield
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane for 9h; Heating;90%
(2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester
185461-75-0

(2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

N-Boc-O-benzyl-L-threonine
15260-10-3

N-Boc-O-benzyl-L-threonine

Conditions
ConditionsYield
With magnesium bromide In dichloromethane for 3h; Ambient temperature; addition at -20 deg C, 0.5 h;83%

15260-10-3Relevant articles and documents

Mizoguchi et al.

, p. 903 (1968)

SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

-

, (2018/03/09)

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

OXABOROLE ESTERS AND USES THEREOF

-

Page/Page column 66, (2017/12/05)

The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.

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