Technology Process of <4'-2H2>-3,5'-O-dibenzylpyridoxine
There total 10 articles about <4'-2H2>-3,5'-O-dibenzylpyridoxine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium deuteride;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
DOI:10.1021/jo00008a071
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) NaH / 1) THF, 30 min, reflux, 2) 4 h, reflux
2: 94 percent / 98percent formic acid / H2O / 24 h / 50 °C
3: 83 percent / NaOMe / methanol / 0.33 h / Ambient temperature
4: 94 percent / pyridinium chlorochromate, NaOAc, 3 Angstroem molecular sieves / CH2Cl2 / 2 h / Ambient temperature
5: 82 percent / 1 M aq. KMnO4, 5percent aq. sodium phosphate / methanol / 1 h / Ambient temperature
6: 89 percent / diethyl ether; methanol / 0 °C
7: 93 percent / LiAlD4 / tetrahydrofuran / 3 h / 0 °C
With
potassium permanganate; formic acid; lithium aluminium deuteride; 3 A molecular sieve; sodium methylate; sodium acetate; sodium hydride; sodium phosphate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo00008a071
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 83 percent / p-TsOH / acetone / 16 h
2: 1) NaH / 1) THF, 30 min, reflux, 2) 4 h, reflux
3: 94 percent / 98percent formic acid / H2O / 24 h / 50 °C
4: 83 percent / NaOMe / methanol / 0.33 h / Ambient temperature
5: 94 percent / pyridinium chlorochromate, NaOAc, 3 Angstroem molecular sieves / CH2Cl2 / 2 h / Ambient temperature
6: 82 percent / 1 M aq. KMnO4, 5percent aq. sodium phosphate / methanol / 1 h / Ambient temperature
7: 89 percent / diethyl ether; methanol / 0 °C
8: 93 percent / LiAlD4 / tetrahydrofuran / 3 h / 0 °C
With
potassium permanganate; formic acid; lithium aluminium deuteride; 3 A molecular sieve; sodium methylate; sodium acetate; sodium hydride; toluene-4-sulfonic acid; sodium phosphate; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo00008a071
