methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride

Base Information

• Chemical Name: methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride
• CAS No.: 1354049-89-0
• Molecular Formula: C₁₄H₁₄ClFP*Cl
• Molecular Weight: 303.143
• Mol file: 1354049-89-0.mol

Synonyms:methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride

Chemical Property of methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride

There total 1 articles about methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-(4-fluoro-2-methylphenyl)methylphenylphosphine oxide (1257102-90-1) → methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride (1354049-89-0)

Guidance literature:

With oxalyl dichloride; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c1cc14856g

Reference yield:

methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride (1354049-89-0) → (+/-)-(4-fluoro-2-methylphenyl)methylphenylphosphine borane (1354049-99-2,1392279-63-8)

Guidance literature:

With sodium tetrahydroborate; In diethylene glycol dimethyl ether; at 20 ℃; for 1h;

DOI:10.1039/c1cc14856g

Reference yield:

(-)-menthol (2216-51-5) + methylphenyl-(2-methyl-4-fluorophenyl) phosphonium chloride (1354049-89-0) → C24H33FOP(1+)*Cl(1-) (1401061-77-5) + C24H33FOP(1+)*Cl(1-) (1401061-78-6)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Overall yield = > 95 %Spectr.; Optical yield = 78 %de; Inert atmosphere;

DOI:10.1039/c2cc34136k

upstream raw materials:

(+/-)-(4-fluoro-2-methylphenyl)methylphenylphosphine oxide

Downstream raw materials:

(+/-)-(4-fluoro-2-methylphenyl)methylphenylphosphine borane

C₂₄H₃₃FOP⁽¹⁺⁾*Cl^(1-)

C₂₄H₃₃FOP⁽¹⁺⁾*Cl^(1-)