tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate
CAS No.:1566543-79-0
Molecular Formula:C₃₁H₃₄F₃N₅O₃
Molecular Weight:581.638
Hs Code.:

Synonyms:tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

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Technology Process of tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

There total 11 articles about tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1566543-78-9
tert-butyl 3-(4-((4-(2-(1-(methoxycarbonyl)cyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

: 1566543-79-0
tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

Guidance literature:: tert-butyl 3-(4-((4-(2-(1-(methoxycarbonyl)cyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 - 35 ℃; for 72h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; at 20 - 40 ℃; for 40h;

Reference yield:

: 1566543-57-4
tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

: 1566543-79-0
tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h

3.1: lithium hydroxide / tetrahydrofuran; water; methanol / 72 h / 20 - 35 °C

3.2: 0.17 h / Inert atmosphere

3.3: 40 h / 20 - 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 883901-62-0
tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate

: 1566543-79-0
tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / ethyl acetate / 18 h

1.2: 20 h

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 h / 20 °C

3.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h

5.1: lithium hydroxide / tetrahydrofuran; water; methanol / 72 h / 20 - 35 °C

5.2: 0.17 h / Inert atmosphere

5.3: 40 h / 20 - 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; zinc(II) chloride; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;