Technology Process of tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate
There total 11 articles about tert-butyl 3-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 3-(4-((4-(2-(1-(methoxycarbonyl)cyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidine-1-carboxylate;
With
lithium hydroxide;
In
tetrahydrofuran; methanol; water;
at 20 - 35 ℃;
for 72h;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
for 0.166667h;
Inert atmosphere;
With
ammonium carbonate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
at 20 - 40 ℃;
for 40h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation
2.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h
3.1: lithium hydroxide / tetrahydrofuran; water; methanol / 72 h / 20 - 35 °C
3.2: 0.17 h / Inert atmosphere
3.3: 40 h / 20 - 40 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / ethyl acetate / 18 h
1.2: 20 h
2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.17 h / 20 °C / Inert atmosphere
2.2: 20 h / 20 °C
3.1: triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation
4.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h
5.1: lithium hydroxide / tetrahydrofuran; water; methanol / 72 h / 20 - 35 °C
5.2: 0.17 h / Inert atmosphere
5.3: 40 h / 20 - 40 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; zinc(II) chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;