tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

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Chemical Name:tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate
CAS No.:1566543-57-4
Molecular Formula:C₁₉H₂₀ClF₃N₄O₂
Molecular Weight:428.842
Hs Code.:

Synonyms:tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

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Chemical Property of tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

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Technology Process of tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

There total 4 articles about tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 916421-36-8
tert-butyl 3-(4-aminophenyl) azetidine-1-carboxylate

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1566543-57-4
tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 0.166667h; Inert atmosphere;

tert-butyl 3-(4-aminophenyl) azetidine-1-carboxylate; With triethylamine; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 20h;

Reference yield:

: 883901-62-0
tert-butyl 3-(4-nitrophenyl)azetidine-1-carboxylate

: 1566543-57-4
tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / ethyl acetate / 18 h

1.2: 20 h

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 h / 20 °C

With hydrogen; zinc(II) chloride; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 254454-54-1
tert-butyl-3-iodoazetidine-1-carboxylate

: 1566543-57-4
tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)azetidi ne-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2.5 h / 20 - 80 °C / Inert atmosphere

1.2: 3 h / 55 °C

2.1: hydrogen / ethyl acetate / 18 h

2.2: 20 h

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 h / 20 °C

With chloro-trimethyl-silane; hydrogen; ethylene dibromide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol;