(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Base Information

Chemical Name:(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine
CAS No.:870724-94-0
Molecular Formula:C₂₈H₃₅NO₃
Molecular Weight:433.591
Hs Code.:

Synonyms:(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Suppliers and Price of (3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

There total 3 articles about (3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 309918-58-9,55606-41-2
(Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide

: 465500-02-1
(1R)-2-endo-propenoyl-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-ol

: 870724-94-0
(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 8.5h;
DOI:10.1002/anie.200502308

Reference yield:

: 464-49-3,68546-28-1
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

: 870724-94-0
(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi; TMDA / tetrahydrofuran; hexane / 0.5 h / -30 °C

1.2: 75 percent / tetrahydrofuran; hexane / 2 h / -30 °C

2.1: 3.12 g / HCl / H₂O; CH₂Cl₂

3.1: 72 percent / Cu(OTf)2 / CH₂Cl₂ / 8.5 h / 20 °C

With hydrogenchloride; n-butyllithium; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1002/anie.200502308

Reference yield:

: 465500-01-0
(1R)-2-endo-(1-methoxy-1,2-propanodienyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

: 870724-94-0
(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 3.12 g / HCl / H₂O; CH₂Cl₂

2: 72 percent / Cu(OTf)2 / CH₂Cl₂ / 8.5 h / 20 °C

With hydrogenchloride; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; water;
DOI:10.1002/anie.200502308