(Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide

Base Information

• Chemical Name: (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide
• CAS No.: 309918-58-9
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• Mol file: 309918-58-9.mol

Synonyms:

Chemical Property of (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide

There total 4 articles about (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-benzylhydroxylamine hydrochloride (29601-98-7) + 4-methyl-benzaldehyde (104-87-0) → (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide (309918-58-9,55606-41-2)

Guidance literature:

With sodium hydrogencarbonate; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.03.091

Reference yield: 72.0%

4-methyl-benzaldehyde (104-87-0) + N-benzyl hydroxylalmine (622-30-0) → (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide (309918-58-9,55606-41-2)

Guidance literature:

In dichloromethane; for 24h; Heating;

DOI:10.1021/jo001393n

Reference yield:

Benzaldoxime (932-90-1) → (Z)-N-(4-methylbenzylidene)-1-phenylmethanamine oxide (309918-58-9,55606-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium cyanoborohydride; hydrogenchloride / water; methanol / 4 h / 20 °C / pH Ca_. 2 / Inert atmosphere

2: sodium sulfate / dichloromethane / 18 h / Inert atmosphere

With hydrogenchloride; sodium cyanoborohydride; sodium sulfate; In methanol; dichloromethane; water;

DOI:10.1002/adsc.201300624

upstream raw materials:

4-methyl-benzaldehyde

N-benzyl hydroxylalmine

N-benzylhydroxylamine hydrochloride

Benzaldoxime

Downstream raw materials:

(3R,4S)-2-benzyl-4-[(1R)-2-exo-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-2-ylcarbonyl]-3-p-methylphenylisoxazolidine