6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

Base Information

Chemical Name:6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile
CAS No.:1187196-43-5
Molecular Formula:C₂₀H₁₀Cl₂F₃N₃O
Molecular Weight:436.22
Hs Code.:

Synonyms:6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

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Chemical Property of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

Chemical Property:

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Technology Process of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

There total 4 articles about 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1187196-70-8
6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 1-oxide

: 1187196-43-5
6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

Guidance literature:: With triethylamine; In acetonitrile; for 6h; Reflux;

Reference yield:

: 39977-56-5
quinoline-6-carbaldehyde-oxime

: 1187196-43-5
6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 - 50 °C

1.2: 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.1: triethylamine / acetonitrile / 6 h / Reflux

With N-chloro-succinimide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4113-04-6
quinoline-6-carbaldehyde

: 1187196-43-5
6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 - 50 °C

2.2: 0 - 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

4.1: triethylamine / acetonitrile / 6 h / Reflux

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;