1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Base Information

Chemical Name:1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester
CAS No.:170750-34-2
Molecular Formula:C₂₂H₂₉NO₇
Molecular Weight:419.475
Hs Code.:

Synonyms:1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

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Chemical Property of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

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Technology Process of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

There total 4 articles about 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 170750-04-6
1-4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-benzyloxypropyl)-3,5-dimethyl ester

: 170750-34-2
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 6h;
DOI:10.1248/cpb.43.818

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 170750-34-2
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / 30percent aq. NH₃ / ethanol / 4 h / Heating

2: NaH / dimethylformamide / 1 h / 100 °C

3: 28 percent / H₂ / 10percent Pd/C / acetic acid; methanol / 6 h

With ammonium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.818

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 170750-34-2
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-hydroxypropyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / 30percent aq. NH₃ / ethanol / 4 h / Heating

2: NaH / dimethylformamide / 1 h / 100 °C

3: 28 percent / H₂ / 10percent Pd/C / acetic acid; methanol / 6 h

With ammonium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.818