5-thyminyl-5,6-dihydrothymine

Base Information

Chemical Name:5-thyminyl-5,6-dihydrothymine
CAS No.:28100-77-8
Molecular Formula:C₁₀H₁₂N₄O₄
Molecular Weight:252.23
Hs Code.:2933599090
Mol file:28100-77-8.mol

Synonyms:2,4(1H,3H)-Pyrimidinedione,dihydro-5-methyl-5-[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)methyl]- (9CI);Hydrouracil, 5-methyl-5-[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)methyl]-(8CI); 5-Thyminyl-5,6-dihydrothymine

Suppliers and Price of 5-thyminyl-5,6-dihydrothymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-thyminyl-5,6-dihydrothymine

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:8.80±0.10(Predicted)
Flash Point:°C
PSA：131.42000
Density:1.353g/cm³
LogP:-0.80810

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-thyminyl-5,6-dihydrothymine

There total 9 articles about 5-thyminyl-5,6-dihydrothymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 188057-25-2
5-(5-Methyl-2,4-dioxo-hexahydro-pyrimidin-5-ylmethyl)-1,3-bis-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

: 28100-77-8
5,6-dihydro-5-(α-thyminyl)thymine

Guidance literature:: With trifluoroacetic acid; at 60 ℃; for 2h;
DOI:10.1016/S0040-4039(96)02517-8

Reference yield:

: 1195-08-0
2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

: 28100-77-8
5,6-dihydro-5-(α-thyminyl)thymine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / NaH / dimethylformamide / 18 h / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

3: PBr₃ / tetrahydrofuran / 0.17 h / Ambient temperature

4: Bu₃SnH, AlBN / toluene / 0.5 h / Heating

5: 40 percent / CAN / acetonitrile; H₂O / 2 h / Ambient temperature

6: 70 percent / TFA / 2 h / 60 °C

With ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; phosphorus tribromide; sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(96)02517-8

Reference yield:

: 188057-14-9
2,4-Dioxo-1,3-bis-(2-trimethylsilanyl-ethoxymethyl)-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 28100-77-8
5,6-dihydro-5-(α-thyminyl)thymine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

2: PBr₃ / tetrahydrofuran / 0.17 h / Ambient temperature

3: Bu₃SnH, AlBN / toluene / 0.5 h / Heating

4: 40 percent / CAN / acetonitrile; H₂O / 2 h / Ambient temperature

5: 70 percent / TFA / 2 h / 60 °C

With ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; phosphorus tribromide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(96)02517-8