Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS No.:188057-17-2
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:
DSSTox Substance ID:DTXSID201141954

Synonyms:DTXSID201141954;Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione;188057-17-2

Suppliers and Price of Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:368.17360725
Heavy Atom Count:27
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CN(C(=O)N(C1=O)CC2=CC=C(C=C2)OC)CC3=CC=C(C=C3)OC

Technology Process of Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

There total 1 articles about Dihydro-1,3-bis[(4-methoxyphenyl)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 824-94-2
p-methoxybenzyl chloride

: 696-04-8
5,6-dihydrothymine

: 188057-17-2
1,3-Bis-(4-methoxy-benzyl)-5-methyl-dihydro-pyrimidine-2,4-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1016/S0040-4039(96)02517-8

Reference yield:

: 188057-17-2
1,3-Bis-(4-methoxy-benzyl)-5-methyl-dihydro-pyrimidine-2,4-dione

: 188057-23-0
5-[1,3-Bis-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-hexahydro-pyrimidin-5-ylmethyl]-1,3-bis-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

2: PBr₃ / tetrahydrofuran / 0.17 h / Ambient temperature

3: Bu₃SnH, AlBN / toluene / 0.5 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; phosphorus tribromide; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(96)02517-8

Reference yield:

: 188057-17-2
1,3-Bis-(4-methoxy-benzyl)-5-methyl-dihydro-pyrimidine-2,4-dione

: 188057-21-8
5-{[1,3-Bis-(4-methoxy-benzyl)-5-methyl-2,4-dioxo-hexahydro-pyrimidin-5-yl]-bromo-methyl}-1,3-bis-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h

2: PBr₃ / tetrahydrofuran / 0.17 h / Ambient temperature

With phosphorus tribromide; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(96)02517-8