Technology Process of Phosphoric acid (2S,3aS,8aR)-2-(2-benzyloxy-ethyl)-2,3,3a,7,8,8a-hexahydro-furo[3,2-b]oxepin-5-yl ester diphenyl ester
There total 11 articles about Phosphoric acid (2S,3aS,8aR)-2-(2-benzyloxy-ethyl)-2,3,3a,7,8,8a-hexahydro-furo[3,2-b]oxepin-5-yl ester diphenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaHMDS / tetrahydrofuran / 0.33 h / 0 °C
1.2: 209.1 mg / tetrahydrofuran / 1 h / 0 °C
2.1: 99 percent / H2 / Pd/C / ethyl acetate; methanol / 5 h / 20 °C
3.1: aq. HCl / tetrahydrofuran / 5 h / 40 - 60 °C
4.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.75 h / 20 °C
5.1: 2,4,6-trichlorobenzoyl chloride; Et3N / tetrahydrofuran / 1.5 h / 20 °C
5.2: 1.95 g / DMAP / tetrahydrofuran; toluene / 0.5 h / Heating
6.1: 979.5 mg / KHMDS; hexamethylphosphoramide / tetrahydrofuran; toluene / 0.67 h / -78 °C
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; hydrogen; sodium hexamethyldisilazane; potassium hexamethylsilazane; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; toluene; tert-butyl alcohol;
1.2: Wittig reaction;
DOI:10.1021/ja042686r
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: SO3*pyridine; Et3N; DMSO / CH2Cl2 / 1.25 h / 0 °C
2.1: NaHMDS / tetrahydrofuran / 0.33 h / 0 °C
2.2: 209.1 mg / tetrahydrofuran / 1 h / 0 °C
3.1: 99 percent / H2 / Pd/C / ethyl acetate; methanol / 5 h / 20 °C
4.1: aq. HCl / tetrahydrofuran / 5 h / 40 - 60 °C
5.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.75 h / 20 °C
6.1: 2,4,6-trichlorobenzoyl chloride; Et3N / tetrahydrofuran / 1.5 h / 20 °C
6.2: 1.95 g / DMAP / tetrahydrofuran; toluene / 0.5 h / Heating
7.1: 979.5 mg / KHMDS; hexamethylphosphoramide / tetrahydrofuran; toluene / 0.67 h / -78 °C
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO3 complex; 2,4,6-trichlorobenzoyl chloride; hydrogen; sodium hexamethyldisilazane; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;
1.1: Swern oxidation / 2.2: Wittig reaction;
DOI:10.1021/ja042686r
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / H2 / Pd/C / ethyl acetate; methanol / 5 h / 20 °C
2.1: aq. HCl / tetrahydrofuran / 5 h / 40 - 60 °C
3.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.75 h / 20 °C
4.1: 2,4,6-trichlorobenzoyl chloride; Et3N / tetrahydrofuran / 1.5 h / 20 °C
4.2: 1.95 g / DMAP / tetrahydrofuran; toluene / 0.5 h / Heating
5.1: 979.5 mg / KHMDS; hexamethylphosphoramide / tetrahydrofuran; toluene / 0.67 h / -78 °C
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; hydrogen; potassium hexamethylsilazane; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; toluene; tert-butyl alcohol;
DOI:10.1021/ja042686r
