1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

Base Information

Chemical Name:1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one
CAS No.:1373242-33-1
Molecular Formula:C₂₆H₂₄FNO₅
Molecular Weight:449.479
Hs Code.:

Synonyms:1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

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Chemical Property of 1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

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Technology Process of 1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

There total 8 articles about 1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1373242-32-0
3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

: 1373242-33-1
1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethyl acetate; for 1h; Reflux;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1373242-33-1
1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 8 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

4.2: 3 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 °C / Inert atmosphere

6.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

7.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 1 h / Reflux

With isopropylmagnesium chloride; ammonium formate; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 313245-18-0
(1-(4-fluoro-benzyl)-1H-indole-2,3-dione)

: 1373242-33-1
1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)-3-(6-hydroxylbenzo[d][1,3]dioxol-5-yl)-indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 8 h / 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

3.2: 3 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 1.5 h / 0 °C / Inert atmosphere

5.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

6.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 1 h / Reflux

With isopropylmagnesium chloride; ammonium formate; sodium hydride; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;