3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

Base Information

Chemical Name:3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one
CAS No.:1373242-32-0
Molecular Formula:C₃₃H₃₀FNO₅
Molecular Weight:539.603
Hs Code.:

Synonyms:3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

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Chemical Property of 3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

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Technology Process of 3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

There total 7 articles about 3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1373242-31-9
ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

: 75-16-1
methylmagnesium bromide

: 1373242-32-0
3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

Guidance literature:: ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate; methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1373242-32-0
3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 8 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

4.2: 3 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 °C / Inert atmosphere

6.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With isopropylmagnesium chloride; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1373242-32-0
3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-3-(2-hydroxy-2-methylpropyl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 8 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

4.2: 3 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 °C / Inert atmosphere

6.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With isopropylmagnesium chloride; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;