5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one

Base Information

• Chemical Name: 5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one
• CAS No.: 1236670-87-3
• Molecular Formula: C₁₂H₉ClN₄O₂
• Molecular Weight: 276.682
• Mol file: 1236670-87-3.mol

Synonyms:2-chloro-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine

Chemical Property of 5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one

Chemical Property:

• PKA: 8.91±0.70(Predicted)
• Density: 1.513±0.06 g/cm3(Predicted)

Purity/Quality:

5-(2-Chloro-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one

There total 1 articles about 5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + 5-amino-2-benzoxazolinone (14733-77-8) → 2-chloro-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine (1236670-87-3)

Guidance literature:

In methanol; water; at 20 ℃; for 64h;

Reference yield: 49.0%

2-chloro-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine (1236670-87-3) + 3-methylsulfonylaniline hydrochloride (80213-28-1) + trifluoroacetic acid (76-05-1) → N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt (1236670-89-5)

Guidance literature:

In isopropyl alcohol; at 85 - 90 ℃; for 40h; closed vial;

Reference yield:

2-chloro-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine (1236670-87-3) + 3,4,5-trimethylaniline hydrochloride → N2-(3,4,5-trimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1236666-76-4)

Guidance literature:

With trifluoroacetic acid; In propan-1-ol; at 107 - 125 ℃; for 102h; under 1050.11 Torr; Solvent; Temperature; Reagent/catalyst; Autoclave;

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

5-amino-2-benzoxazolinone

Downstream raw materials:

N₄-(benzo[d]oxazol-2(3H)-on-5-yl)-N₂-(3-methylsulfonylphenyl)-5-methylpyrimidine-2,4-diamine mono-trifluoroacetate salt

N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

di-tert-butyl (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate