(1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide

Base Information

• Chemical Name: (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide
• CAS No.: 872047-95-5
• Molecular Formula: C₂₃H₃₄N₂O₆S₂
• Molecular Weight: 498.665

Synonyms:(1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide

Chemical Property of (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide

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Technology Process of (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide

There total 3 articles about (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1R,2R)-(2-aminocyclohexyl)-4-methoxy-benzenesulfonamide (1047662-99-6) + Camphorsulfonyl chloride (21286-54-4) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide (872047-95-5)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 ℃; for 24h;

DOI:10.1016/j.tetasy.2005.08.031

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide (872047-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / CH₂Cl₂ / 6 h / 0 - 25 °C

2: DMAP; Et₃N / acetonitrile / 24 h / 0 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/chem.200501397

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → (1S,4R,1'R,2'R)-N-{trans-2'-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethylsulfonamino]cyclohexyl}-4''-methoxybenzenesulfonamide (872047-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / CH₂Cl₂ / 6 h / 0 - 25 °C

2: DMAP; Et₃N / acetonitrile / 24 h / 0 °C

With dmap; sodium hydroxide; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/chem.200501397

upstream raw materials:

N-(1R,2R)-(2-aminocyclohexyl)-4-methoxy-benzenesulfonamide

Camphorsulfonyl chloride

(1R,2R)-1,2-diaminocyclohexane

4-methoxy-phenyl-sulphonyl chloride

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