3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

Base Information

Chemical Name:3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate
CAS No.:1363374-91-7
Molecular Formula:C₂₃H₂₅FN₂O₅S
Molecular Weight:460.526
Hs Code.:

Synonyms:3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

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Chemical Property of 3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

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Technology Process of 3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

There total 9 articles about 3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1415910-87-0
3-(nitrooxy)propyl N-((benzyloxy)carbonyl)-2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetate

: 1363374-91-7
3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:: With palladium on activated charcoal; ammonium formate; In isopropyl alcohol; at 80 ℃; for 0.0833333h; under 8791.75 Torr; Microwave irradiation;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield: 45.0%

: 1363374-91-7
3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:

Reference yield:

: ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

: 1363374-91-7
3-(hydroxy)propyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

2: zinc; formic acid / ethanol / 0 - 20 °C

3: sodium carbonate / dichloromethane / 4 h / 0 - 20 °C

4: sodium hydroxide; water / methanol / 17 h

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / Inert atmosphere

6: ammonium formate; palladium on activated charcoal / isopropyl alcohol / 0.08 h / 80 °C / 8791.75 Torr / Microwave irradiation

With dmap; formic acid; palladium on activated charcoal; hydroxylamine hydrochloride; water; ammonium formate; sodium acetate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.ejmech.2012.10.014