1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE

Base Information

Chemical Name:1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE
CAS No.:189500-90-1
Molecular Formula:C18H16FNO2S
Molecular Weight:329.395
Hs Code.:
Mol file:189500-90-1.mol

Synonyms:2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[4-(fluoro)phenyl]-1H-pyrrole;1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrole;1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrole;1-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-5-methyl-1H-pyrrole;1-(4-Fluorophenyl)-5-methyl-2-(4-methylsulfonylphenyl)pyrrole;

Suppliers and Price of 1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE 95.00%
10MG
$ 679.14

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE 95.00%
1MG
$ 647.61

Total 0 raw suppliers

Chemical Property of 1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE

Chemical Property:

Melting Point:157 °C
PSA：47.45000
LogP:5.07610

Purity/Quality:: 1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE

There total 4 articles about 1-(4-FLUOROPHENYL)-2-METHYL-5-[4-(METHYLSULFONYL)PHENYL]-1H-PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 371-40-4
4-fluoroaniline

: 189501-34-6
1-[4-(methylsulfonyl)phenyl]pentane-1,4-dione

: 189500-90-1
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 20h; Heating;
DOI:10.1021/jm0707525

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 189500-90-1
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 75 °C

2: aq. phosphate buffer; acetonitrile / 23 °C / pH 7.2

With triethylamine; In aq. phosphate buffer; ethanol; acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1039/d0ra06962k

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 189500-90-1
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / oxone / methanol; H₂O / 2 h / 25 °C

2: 79 percent / p-TsOH / toluene / 20 h / Ambient temperature

With Oxone; toluene-4-sulfonic acid; In methanol; water; toluene;
DOI:10.1021/jm970036a