imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

Base Information

Chemical Name:imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide
CAS No.:1453173-85-7
Molecular Formula:C₂₁H₂₂F₃N₅O₃S
Molecular Weight:481.499
Hs Code.:

Synonyms:imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

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Chemical Property of imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

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Technology Process of imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

There total 5 articles about imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1453176-72-1
4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamine

: 139022-25-6
imidazo[1,2-a]pyridine-6-carboxylic acid

: 1453173-85-7
imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

Guidance literature:: imidazo[1,2-a]pyridine-6-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; at 25 ℃; for 0.166667h;

4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamine; at 25 ℃; for 12h;

Reference yield:

: 913518-73-7
4-(4-cyanobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester

: 1453173-85-7
imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 5 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C

3.1: hydrogen; ammonia / methanol / 2 h / 25 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 0.17 h / 25 °C

4.2: 12 h / 25 °C

With ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 870761-05-0
4-(piperazin-1-ylsulfonyl)benzonitrile

: 1453173-85-7
imidazo[1,2-a]pyridine-6-carboxylic acid 4-[4-(2,2,2-trifluoroethyl)piperazine-1-sulfonyl]benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C

2.1: hydrogen; ammonia / methanol / 2 h / 25 °C / 760.05 Torr

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 0.17 h / 25 °C

3.2: 12 h / 25 °C

With ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;