2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

Base Information

Chemical Name:2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester
CAS No.:851962-05-5
Molecular Formula:C₂₆H₂₈Cl₂N₂O₄S₂
Molecular Weight:567.557
Hs Code.:

2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid <i>tert</i>-butyl ester

Synonyms:2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

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Chemical Property of 2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

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Technology Process of 2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

There total 6 articles about 2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 851962-03-3
tert-butyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate

: 851961-97-2
2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethanol

: 851962-05-5
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 1h;
DOI:10.1021/ja042929f

Reference yield:

: 851962-02-2
tert-butyl 2-(4-benzyloxy-3,5-dichlorophenylamino)benzoate

: 851962-05-5
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / H₂ / Pd/C / methanol; ethyl acetate / 16 h

2: 76 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 2: Mitsunobu reaction;
DOI:10.1021/ja042929f

Reference yield:

: 55666-42-7
tert-butyl 2-bromobenzoate

: 851962-05-5
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / tris(dibenzylidenoacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate / toluene / 24 h / Heating

2: 89 percent / H₂ / Pd/C / methanol; ethyl acetate / 16 h

3: 76 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene; 3: Mitsunobu reaction;
DOI:10.1021/ja042929f