ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
• CAS No.: 201287-93-6
• Molecular Formula: C₁₄H₁₅FN₂O₂S
• Molecular Weight: 294.35
• Mol file: 201287-93-6.mol

Synonyms:4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ^*data from reagent suppliers

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Technology Process of ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE

There total 5 articles about ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl acetoacetate (141-97-9) + 4-fluorobenzaldehyde (459-57-4) + thiourea (17356-08-0) → 4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (201287-93-6)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 114 ℃; for 0.0833333h; Microwave irradiation;

Reference yield: 85.0%

ammonium thiocyanate (1147550-11-5) + ethyl acetoacetate (141-97-9) + 4-fluorobenzaldehyde (459-57-4) → 4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (201287-93-6)

Guidance literature:

In neat (no solvent); at 110 ℃; for 1h;

DOI:10.1016/j.tetlet.2017.03.070

Reference yield: 78.0%

thioacetone (4756-05-2) + ethyl acetoacetate (141-97-9) + 4-fluorobenzaldehyde (459-57-4) → 4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (201287-93-6)

Guidance literature:

With aluminium oxide hydroxide; In neat (no solvent); at 120 ℃; for 1.5h; Green chemistry;

DOI:10.1016/S1872-2067(12)60759-1

upstream raw materials:

ethyl acetoacetate

4-fluorobenzaldehyde

thiourea

thioacetone

Downstream raw materials:

4-(4-fluoro-phenyl)-6-methyl-2-pentylsulfanyl-1, 4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

4-(4-fluoro-phenyl)-6-methyl-2-tetradecylsulfanyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

C₁₄H₁₅FN₂O₂

4-(4-fluorophenyl)-2-hydroxy-6-methylpyrimidine-5-carboxylic acid ethyl ester

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