diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

Base Information

Chemical Name:diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)
CAS No.:1606128-29-3
Molecular Formula:C₂₈H₂₄F₂N₄O₄S₂
Molecular Weight:582.652
Hs Code.:

Synonyms:diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

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Chemical Property of diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

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Technology Process of diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

There total 3 articles about diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 201287-93-6
4-(4-fluoro-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

: 1606128-29-3
diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 6h; Cooling with ice; Inert atmosphere; Schlenk technique;
DOI:10.1002/adsc.201300776

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1606128-29-3
diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

Guidance literature:: Multi-step reaction with 2 steps

1: PS-PEG-SO₃H₂ / 1,4-dioxane; isopropyl alcohol / 10 h / 80 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydride / 1,4-dioxane / 8 h / 20 °C

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1002/ejoc.201801565

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1606128-29-3
diethyl 2,2'-disulfanediylbis(4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylate)

Guidance literature:: Multi-step reaction with 2 steps

1: PS-PEG-SO₃H₂ / 1,4-dioxane; isopropyl alcohol / 10 h / 80 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydride / 1,4-dioxane / 8 h / 20 °C

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1002/ejoc.201801565