bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Base Information

Chemical Name:bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
CAS No.:331001-05-9
Molecular Formula:C₂₄H₂₇F₂NO₉
Molecular Weight:511.476
Hs Code.:

Synonyms:bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

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Chemical Property of bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

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Technology Process of bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

There total 1 articles about bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 57582-45-3
ethoxycarbonylmethyl acetoacetate

: 331001-05-9
bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Guidance literature:: With ammonium hydroxide; In ethanol; for 6h; Heating;
DOI:10.1016/S0957-4166(00)00441-9

Reference yield: 47.0%

: 331001-05-9
bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

: (+)-4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethyl-5-ethoxycarbonylmethoxycarbonyl-3-pyridinecarboxylic acid

Guidance literature:: With CAL B; In di-isopropyl ether; water; at 45 ℃; for 282h; pH=7.5;
DOI:10.1016/S0957-4166(00)00441-9

Reference yield:

: 331001-05-9
bis(ethoxycarbonylmethyl) 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

: ethoxycarbonylmethyl methoxycarbonylmethyl 4-(2'-difluoromethoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / CAL B / diisopropyl ether; H₂O / 282 h / 45 °C / pH 7.5

2: 80 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

With potassium carbonate; In di-isopropyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(00)00441-9