1-(2-PhthaliMidobutanoyl)chloride

Base Information

• Chemical Name: 1-(2-PhthaliMidobutanoyl)chloride
• CAS No.: 10314-06-4
• Molecular Formula: C12H10ClNO3
• Molecular Weight: 251.669
• Hs Code.: 2925199590
• Mol file: 10314-06-4.mol

Synonyms:4-(1,3-dioxoisoindol-2-yl)butanoyl chloride;

Chemical Property of 1-(2-PhthaliMidobutanoyl)chloride

Chemical Property:

• Vapor Pressure: 3.28E-06mmHg at 25°C
• Boiling Point: 387.5oC at 760 mmHg
• Flash Point: 188.2oC
• PSA: 54.45000
• Density: 1.385g/cm3
• LogP: 1.76610

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Phthalimidobutyryl)chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-PhthaliMidobutanoyl)chloride

There total 11 articles about 1-(2-PhthaliMidobutanoyl)chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-phthalimidobutyric acid (3130-75-4) → 4-phthalimidobutyryl chloride (10314-06-4)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 6h; Heating;

DOI:10.1002/ejoc.200601067

Reference yield:

phthalic anhydride (85-44-9) → 4-phthalimidobutyryl chloride (10314-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 6 h / 170 °C

2: 100 percent / oxalyl chloride / CH₂Cl₂ / 6 h / Heating

With oxalyl dichloride; In dichloromethane;

DOI:10.1002/ejoc.200601067

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → 4-phthalimidobutyryl chloride (10314-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / water / 3 h / 20 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

With oxalyl dichloride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.8b02737

upstream raw materials:

4-phthalimidobutyric acid

phthalic anhydride

4-amino-n-butyric acid

potassium phtalimide

Downstream raw materials:

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyramide

2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione

methylene chloride

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate