2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

Base Information

Chemical Name:2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide
CAS No.:83604-97-1
Molecular Formula:C₂₄H₃₁ClN₂O₃
Molecular Weight:430.975
Hs Code.:

Synonyms:2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

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Chemical Property of 2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

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Technology Process of 2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

There total 5 articles about 2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 83604-97-1
2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 98.7 percent / acetic acid / 6 h / 60 °C

2: Na, propanol / 1 h / Heating

3: conc. HCl / propan-2-ol; H₂O / 6 h / 20 - 130 °C

4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

With hydrogenchloride; propan-1-ol; sodium; acetic acid; lithium diisopropyl amide; In water; isopropyl alcohol;
DOI:10.1021/jm00355a010

Reference yield:

: 14318-66-2
3-methoxy-N-methylaniline

: 83604-97-1
2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 1 h / 20 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

With triethylamine; lithium diisopropyl amide; In chloroform;
DOI:10.1021/jm00355a010

Reference yield:

: 1-[2-(2-Chloro-phenyl)-ethyl]-4-oxo-piperidine-3-carboxylic acid ethyl ester

: 83604-97-1
2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(3-methoxy-phenyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: conc. HCl / propan-2-ol; H₂O / 6 h / 20 - 130 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

With hydrogenchloride; lithium diisopropyl amide; In water; isopropyl alcohol;
DOI:10.1021/jm00355a010