{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

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Chemical Name:{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester
CAS No.:1218931-31-7
Molecular Formula:C₃₂H₅₄N₄O₆
Molecular Weight:590.804
Hs Code.:

{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Synonyms:{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

There total 13 articles about {2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1218931-27-1
4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

: 109183-71-3
N-(tert-butoxycarbonyl)-L-cyclohexylglycine

: 1218931-31-7
{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: 4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In methanol; for 3h; under 2844.39 Torr;

N-(tert-butoxycarbonyl)-L-cyclohexylglycine; With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 16h;

Reference yield:

: 850003-05-3
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

: 1218931-31-7
{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: pyridine-SO₃ complex; triethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

3.1: triethylamine / 12 h

3.2: 1 h / -78 °C

3.3: 1 h / -78 °C

4.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

5.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

5.2: 16 h / 0 - 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

9.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

9.3: 16 h / 0 - 20 °C

10.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 2844.39 Torr

10.2: 16 h / 0 - 20 °C

With sodium tetrahydroborate; lithium borohydride; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 757247-71-5
tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

: 1218931-31-7
{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 12 h

1.2: 1 h / -78 °C

1.3: 1 h / -78 °C

2.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

3.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

3.2: 16 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

7.3: 16 h / 0 - 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 2844.39 Torr

8.2: 16 h / 0 - 20 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;