N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Base Information

Chemical Name:N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide
CAS No.:1218931-30-6
Molecular Formula:C₃₀H₅₂N₆O₄
Molecular Weight:560.781
Hs Code.:

N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Synonyms:N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Suppliers and Price of N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

There total 14 articles about N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1218931-31-7
{2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

: 21691-41-8
(2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid

: 1218931-30-6
N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: {2-[4-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

(2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 16h;

With hydrogen; palladium 10% on activated carbon; In methanol; for 2h; under 2844.39 Torr;

Reference yield:

: 850003-05-3
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

: 1218931-30-6
N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: pyridine-SO₃ complex; triethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

3.1: triethylamine / 12 h

3.2: 1 h / -78 °C

3.3: 1 h / -78 °C

4.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

5.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

5.2: 16 h / 0 - 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

9.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

9.3: 16 h / 0 - 20 °C

10.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 2844.39 Torr

10.2: 16 h / 0 - 20 °C

11.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

11.2: 16 h / 0 - 20 °C

11.3: 2 h / 2844.39 Torr

With sodium tetrahydroborate; lithium borohydride; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1218929-35-1
(3S)-(tert-butyl-dimethyl-silanyloxy)-(2R)-(2-nitro-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1218931-30-6
N-(1-cyclohexyl-2-{4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrol-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

2.2: 16 h / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

6.3: 16 h / 0 - 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 2844.39 Torr

7.2: 16 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

8.2: 16 h / 0 - 20 °C

8.3: 2 h / 2844.39 Torr

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;