(2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one

Base Information

• Chemical Name: (2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one
• CAS No.: 881748-07-8
• Molecular Formula: C₂₃H₃₅NO₂
• Molecular Weight: 357.536

Synonyms:(2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one

Chemical Property of (2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one

Chemical Property:

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Technology Process of (2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one

There total 1 articles about (2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2S,4aS,7R,8aR)-N-benzyl-2-(N-methyl-N-methoxyaminocarbonyl)-4,4,7-trimethyloctahydrobenzo[e][1,3]oxazine (848033-62-5) + n-butyllithium (109-72-8,29786-93-4) → (2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one (881748-07-8)

Guidance literature:

In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

DOI:10.1021/jo052458v

Reference yield: 92.0%

(2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one (881748-07-8) + (trifluoromethyl)trimethylsilane (81290-20-2) → (2R,2S',4a'S,7'R,8a'R)-2-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-1,1,1-trifluorohexan-2-ol + (2S,2S',4a'S,7'R,8a'R)-2-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-1,1,1-trifluorohexan-2-ol (881748-24-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo052458v

Reference yield:

(2S,4aS,7R,8aR)-1-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)pentan-1-one (881748-07-8) + (trifluoromethyl)trimethylsilane (81290-20-2) → (2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-2-(1-trifluoromethyl-1-trimethylsilanyloxy-pentyl)-octahydro-benzo[e][1,3]oxazine

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jo052458v

upstream raw materials:

(2S,4aS,7R,8aR)-N-benzyl-2-(N-methyl-N-methoxyaminocarbonyl)-4,4,7-trimethyloctahydrobenzo[e][1,3]oxazine

n-butyllithium

Downstream raw materials:

(2S,2S',4a'S,7'R,8a'R)-2-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-1,1,1-trifluorohexan-2-ol

(2S)-N-benzyl-N-(2-trifluoromethyl-2-hydroxyhexan-1-yl)-8'-aminomenthol

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