tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
CAS No.:1566584-72-2
Molecular Formula:C₃₁H₃₅F₄N₅O₃
Molecular Weight:601.644
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1566584-71-1
lithium 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)-4-fluorophenyl)acetate

: 1566584-72-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 40 ℃;

Reference yield:

: 61150-59-2
2-(2-bromo-4-fluorophenyl)acetic acid

: 1566584-72-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / water / 20 °C

2: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 35 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.03 h

4: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

6: lithium hydroxide monohydrate / water; tetrahydrofuran / 40 °C

7: triethylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 936693-19-5
methyl 2-(4-fluoro-2-((trimethylsilyl)ethynyl)phenyl)acetate

: 1566584-72-2
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)-5-fluorophenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.03 h

2: copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 40 °C

5: triethylamine; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;