2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Base Information

Chemical Name:2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione
CAS No.:1188432-62-3
Molecular Formula:C₁₉H₁₇F₃N₂O₄
Molecular Weight:394.35
Hs Code.:

Synonyms:2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

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Chemical Property of 2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Chemical Property:

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Technology Process of 2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

There total 8 articles about 2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188432-64-5
7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylic acid

: 504-02-9
1,3-cylohexanedione

: 121-44-8
triethylamine

: 1188432-62-3
2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Guidance literature:: 7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylic acid; 1,3-cylohexanedione; With dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 1h; Molecular sieve;

triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; at 20 ℃; for 2h; Molecular sieve;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 1188432-62-3
2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine / ethanol / 2 h / Reflux

2.1: ammonium peroxydisulfate; sulfuric acid; silver nitrate / dichloromethane; water / 40 °C

3.1: sodium tetrahydroborate; ethanol / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: methanol / 0.5 h / 20 °C

5.2: 1 h

6.1: dicyclohexyl-carbodiimide / acetonitrile / 1 h / 20 °C / Molecular sieve

6.2: 2 h / 20 °C / Molecular sieve

With piperidine; ammonium peroxydisulfate; sodium tetrahydroborate; ethanol; sulfuric acid; silver nitrate; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 252959-76-5
ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

: 1188432-62-3
2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium peroxydisulfate; sulfuric acid; silver nitrate / dichloromethane; water / 40 °C

2.1: sodium tetrahydroborate; ethanol / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 1 h

5.1: dicyclohexyl-carbodiimide / acetonitrile / 1 h / 20 °C / Molecular sieve

5.2: 2 h / 20 °C / Molecular sieve

With ammonium peroxydisulfate; sodium tetrahydroborate; ethanol; sulfuric acid; silver nitrate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; acetonitrile;