Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
CAS No.:252959-76-5
Molecular Formula:C₁₂H₉F₃N₂O₂
Molecular Weight:270.211
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40382190
Wikidata:Q82173511
Mol file:252959-76-5.mol

Synonyms:ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate;252959-76-5;Peakdale1_000021;SCHEMBL123322;HMS518A21;DTXSID40382190;MFCD00202892;1,8-Naphthyridine-3-carboxylicacid,2-(trifluoromethyl)-,ethylester(9CI);AKOS023117294;PS-6349;CS-0088350;E84055;SR-01000385144;SR-01000385144-1;ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate;ethyl 2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylate;2-Trifluoromethyl-[1,8]naphthyridine-3-carboxylic acid ethyl ester;1,8-naphthyridine-3-carboxylic acid,2-(trifluoromethyl)-,ethyl ester

Suppliers and Price of Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
25mg
$ 45.00

SynQuest Laboratories
Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
1 g
$ 111.00

Crysdot
Ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate 95+%
5g
$ 564.00

Apolloscientific
Ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
5g
$ 207.00

Apolloscientific
Ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
1g
$ 69.00

Total 7 raw suppliers

Chemical Property of Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

Chemical Property:

PSA：52.08000
LogP:2.82530
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:270.06161202
Heavy Atom Count:19
Complexity:335

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C2C(=C1)C=CC=N2)C(F)(F)F
Uses Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

Technology Process of Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

There total 1 articles about Ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7521-41-7
2-Aminonicotinaldehyde

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

: 252959-76-5
ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

Guidance literature:: With sodium hydrogensulfate on silicagel; In neat (no solvent); at 80 ℃; for 0.5h; Green chemistry;

Reference yield:

: 252959-76-5
ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

: 1188432-62-3
2-[7-(1-methoxyethyl)-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl]-cyclohexane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium peroxydisulfate; sulfuric acid; silver nitrate / dichloromethane; water / 40 °C

2.1: sodium tetrahydroborate; ethanol / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 1 h

5.1: dicyclohexyl-carbodiimide / acetonitrile / 1 h / 20 °C / Molecular sieve

5.2: 2 h / 20 °C / Molecular sieve

With ammonium peroxydisulfate; sodium tetrahydroborate; ethanol; sulfuric acid; silver nitrate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 252959-76-5
ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate

: 2-Trifluoromethyl-[1,8]naphthyridine-3-carboxylic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / hydrazine hydrate / methanol / 8 h / Heating

2: 86 percent / CH₃COOH / methanol / 4 h / Heating

With hydrazine hydrate; acetic acid; In methanol; 1: Substitution / 2: Arylation;