[(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Base Information

• Chemical Name: [(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone
• CAS No.: 134389-37-0
• Molecular Formula: C₁₇H₂₇NO₃
• Molecular Weight: 293.406
• Mol file: 134389-37-0.mol

Synonyms:[(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Chemical Property of [(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

There total 1 articles about [(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2'S,6S)-1-<3-<(tert-butyldimethylsilyl)oxy>propyl>-6-methyl-6-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1,4-cyclohexadiene (134389-36-9) → [(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (134389-37-0)

Guidance literature:

With hydrogen fluoride; In acetonitrile; for 0.5h;

DOI:10.1021/ja00013a032

Reference yield:

[(S)-2-(3-Hydroxy-propyl)-1-methyl-cyclohexa-2,5-dienyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (134389-37-0) + methyl iodide (74-88-4) → (2'S,6S)-1-(3-methyoxypropyl)-6-methyl-6-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1,4-cyclohexadiene

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 5 min, 2.) THF, Rt, overnight;

DOI:10.1021/ja00013a032

upstream raw materials:

(2'S,6S)-1-<3-<(tert-butyldimethylsilyl)oxy>propyl>-6-methyl-6-<<2'-(methoxymethyl)pyrrolidinyl>carbonyl>-1,4-cyclohexadiene